Manchester City face Stoke City in the FA Cup final at Wembley at 1400 GMT by which time the day's English Premier League games will be over and United, should they draw at Blackburn Rovers, will be celebrating their 19th title and 12th under manager Alex Ferguson.
Manchester United dropped their first points of the season in a 1-1 draw at Stoke City on Saturday but ended the day top of the Premier League while Chelsea striker Fernando Torres scored and was sent off in his side's 4-1 win over Swansea City.
Photos from the English Premier League matches played on Wednesday
Manchester City went top of the Premier League, at least until Manchester United play at Stoke City later on Saturday, when they beat Everton 2-0 at the Etihad Stadium with goals from second-half substitutes Mario Balotelli and James Milner.
Charlie Adam scored twice as Stoke City beat Manchester United 2-1 on Saturday to show the flailing Premier League champions it will take more than one big-money signing to improve their fortunes.
Wayne Rooney's 21st Premier League goal of the season secured a 1-0 victory for Manchester United over Fulham on Monday to put them three points clear of Manchester City in the title race.
Manchester United striker Javier Hernandez was close to quitting football last year, his father Javier Hernandez Gutierrez has revealed.
'If you look at the points we've lost at home -- all the matches where we draw -- you're thinking about 10 or 12 and, with these points we wouldn't just be speaking about the top four, we'd be speaking about the top two or the top one'
Champions Manchester United's hopes of retaining their English Premier League title suffered another major setback on Saturday when they were beaten 1-0 at Old Trafford by a composed Newcastle United.
Willian's late strike snatched a 1-0 home win for Chelsea over a stubborn Everton side to maintain lead.
'Before the start of the season I felt Manchester United will be a lot better this year and they were my tip for the title'
A goal in added time by Diego Costa earned Chelsea a 1-1 draw against Manchester United on Sunday and preserved Guus Hiddink's unbeaten record while denying Dutch compatriot Louis van Gaal victory.
United suffered their fourth successive defeat in all competition on Saturday when they were beaten by Stoke in the Premier League -- a result that extended their winless run to seven games.
Michael Owen struck twice in his first game of the season as Manchester United thrashed bitter rivals Leeds United 3-0 in a League Cup third-round tie at Elland Road on Tuesday.
Manchester United will kick-off their title defence away to West Bromwich Albion on August 13, the Premier League said on Friday. Runners-up Chelsea are also away from home on the opening day of the 2011/12 season, when they head to FA Cup finalists Stoke City.
Manchester United's players had already switched their body clocks back to GMT before beating Ecuador's LDU to capture the Club World Cup in Japan. The Premier League champions became the tournament's first British winners when a Wayne Rooney goal gave them a 1-0 victory over LDU in Sunday's final in Yokohama.
Daley Blind's injury-time equaliser rescued a 1-1 draw for Manchester United against West Ham United on Sunday but a point was not enough to regain third spot in the Premier League.
Holders Manchester United, featuring an on-target Michael Owen among their second string, reached the League Cup quarter-finals with a 2-0 victory at Championship (second division) side Barnsley on Tuesday.
Images from Saturday's third round matches in the FA Cup.
Manchester United midfielder Angel Di Maria will miss Tuesday's game against Stoke City and is set for an extended spell on the sidelines after limping out of Saturday's 3-0 win over Hull City.
A turbo-charged start yielding two goals in the opening 15 minutes and a spectacular effort by Tom Cleverley led Manchester United to a 3-0 victory at Newcastle United in the Premier League on Sunday.
A sensational solo goal by Nani and a Michael Owen header earned Manchester United a point as they twice came from behind to draw 2-2 at Bolton Wanderers in a lively lunchtime kickoff in the Premier League on Sunday.
Saturday's clash between Manchester United and Tottenham Hotspur at Old Trafford is already shaping up as an early-season eliminator to challenge runaway leaders Manchester City for the Premier League title.
After a week when Wayne Rooney hogged the headlines, his stand-in Javier Hernandez scored twice to secure Manchester United's first away win in the Premier League this season in a 2-1 triumph at Stoke City on Sunday.
Arsenal are going through a sticky patch, goals and points are drying up and injuries are mounting, so it is not the best time to entertain Manchester United on Saturday. Chelsea, who returned to the top last week on goal difference with a 5-0 thrashing of Sunderland, are at Blackburn Rovers on Sunday while Liverpool, stunned 2-1 at Tottenham Hotspur, are at home to West Bromwich Albion on Saturday.
Manchester City withdrew from the battle to secure the services of Arsenal's Chilean forward Alexis Sanchez, leaving Jose Mourinho's Manchester United as the most likely destination for the 29-year-old.
Chelsea and Liverpool maintained their unbeaten starts to the season and kept the pressure on early pace-setters Arsenal when they both chalked up 2-0 away wins in the Premier League on Saturday.
Manchester United's winless run continued but they gave under-fire coach Louis van Gaal crumbs of cheer with a committed display in an entertaining 0-0 draw with Chelsea while Arsenal went top of the table on Monday.
The game at Huddersfield is the first meeting between the clubs since 1972 and the Yorkshire side have not won one since 20 years before that, in March 1952.
Jamie Vardy became the first player to score in 11 consecutive Premier League matches when he gave Leicester City the lead in a 1-1 draw with Manchester United at the King Power Stadium on Saturday.
Premier League leaders Leicester City moved even closer to the title by winning 2-0 at relegation-threatened Sunderland on Sunday. England international Jamie Vardy put them ahead in the 66th minute and he added his second -- and 21st of the season -- in added time. That left them 10 points ahead of second-placed Tottenham Hotspur, who play Manchester United later on Sunday. With five games left, Claudio Ranieri's unfashionable side need a maximum of nine more points to become English champions for the first time. Sunderland remain in the bottom three, four points behind Norwich City, who they play next Saturday. "It was tough, we knew it would be, but we ground it out," Vardy told Sky Sports. "We know it's a step closer but you never know what can happen. "The main thing now is we've got to take it into the next week."
Chelsea offered a chink of light to Manchester City in the Premier League title race after a stormy 1-1 home draw with Burnley on Saturday that gave more ammunition to their outspoken manager Jose Mourinho.
Jamie Vardy's record scoring streak ended but LeicesterCity's improbable Premier League title challenge continued with Riyad Mahrez's hat-trick sealing a 3-0 win at SwanseaCity that put them top on Saturday.
The plucky underdogs were brought down to earth as Manchester City, Everton and Stoke City reached the League Cup semi-finals on Tuesday, ending the hopes of second-tier sides who felled fancied opponents in the last round.
Wayne Rooney ended his eight-game Premier League scoring drought with a 2-0 victory against a dogged Sunderland.
Chelsea surged to the top of the Premier League with a 3-0 home win over Stoke City thanks to goals from Mohamed Salah, Frank Lampard and Willian at Stamford Bridge on Saturday.
Anthony Martial introduced himself to Manchester United fans with a superb goal to complete a 3-1 win over bitter rivals Liverpool and cap a much-improved performance from Louis van Gaal's side on Saturday.
Manchester United enjoyed perhaps their finest performance.
Antonio Valencia's early thunderbolt put Manchester United en route to a 4-0 Premier League victory over Everton on Sunday, but they needed a flurry of late goals to finally subdue their unfortunate visitors.
Manchester City continued their imperious start to the season with a 2-1 win over Swansea City to reach the fourth round of the League Cup on Wednesday but it was a testing night for rivals United who eventually overcame Northampton Town 3-1.